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Pinto RA, Costa D, Morgado A et al: Intratrigonal onabotulinumtoxina improves bladder symptoms and quality of life in patients with bladder pain syndrome/interstitial cystitis: A pilot, single center, randomized, double-blind, placebo controlled trial

Gingival crevicular fluid shows significantly reduced GSH concentrations and markedly elevated 4-HNE levels ( 2.4 The ferroptosis-inflammation vicious cycle drives chronic periodontitis Growing evidence indicates that ferroptosis can trigger inflammatory responses, while the inflammatory microenvironment further promotes ferroptosis, forming a self-amplifying vicious cycle that drives the persistent progression of chronic periodontitis

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