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The classical example of this was the recognition that an APAP overdose in the mouse causes the formation of a reactive metabolite, which first depletes glutathione (GSH) and then binds to sulfhydryl groups of proteins triggering cell death [79]

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A GST-tagged protein is immobilized on glutathione agarose beads and used to pull down interacting proteins from a complex mixture, such as cell lysate, or using purified recombinant proteins

These have decades of clinical evidence behind them, are far cheaper than glutathione courses, and have predictable outcomes