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Additionally, PXN HIGH further augmented BDNF (Fig

By inducing TGF-3 expression and activating the Smad3 pathway, it subsequently upregulates NOX4 and promotes ROS production, ultimately achieving positive reinforcement of E-P-OS network activity [72]

Hormonal imbalances : Hormonal fluctuations due to menstruation, PCOS, and even pregnancy can lead to an increase in sebum production

Further, the locomotor activity was determined using an open field test (OFT), and depression-related behavior was determined using a tail suspension test (TST) and forced swim test (FST)