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In the face, for instance, direct exposure of the skin to smoke induces high levels of oxidative stress associated with the skin barrier disruption, whereas in the less exposed areas such as the volar forearm, the compensatory processes may maintain the barrier function

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This includes enforcing restrictions on marketing tactics that appeal to youth, such as banning all non tobacco flavors (including mint/menthol and coolants), restricting online sales and social media promotion, and prohibiting misleading tobacco free or implicit health claims (4, 7)

and (e) smoking imposes uncompensated costs on the American health system