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by 36 and 42 hpi, this transcriptional signature shifted to genes associated with merozoite-related structures and functionsincluding rhoptries, the apical complex, the apical region of the cell, and the actin cytoskeleton

Less common, but potentially deadly, include involvement of the liver/gallbladder, lung, pancreas, and kidneys.

Result: p53 nuclear exclusion, mitochondrial translocation, and apoptosis

The method of embodiment3, wherein the chemotherapy-induced ototoxicity is caused by a platinum based chemotherapeutic agent, a bis-platinate, vincristine, an aminoglycoside antibiotic, a macrolide antibiotic, a diuretic or a salicylate