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[DOI] [PubMed] [Google Scholar] 41.Almeida B.F.M., Narciso L.G., Melo L.M., Preve P.P., Bosco A.M., Lima V.M.F., Ciarlini P.C

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Apoptotic cell death mechanism has two main pathways, intrinsic ( via mitochondria) and extrinsic ( via death receptors) pathways (Grancara et al., 2016

Pharmacokinetics and Dose Relationship The cagrilintide dose directly influences: Peak plasma concentration : Higher doses = higher peak levels Duration of action : Extended half-life maintains effects for 7+ days Receptor occupancy : 2.4 mg achieves optimal receptor saturation Metabolic effects : Dose-dependent weight loss and metabolic improvements Understanding these mechanisms helps explain why the 2.4 mg dose was selectedit achieves optimal receptor activation without excessive side effects