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An untreated vitamin B12 deficiency can lead to neurological problems or pernicious anaemia, which occurs when your body does not have enough B12 to produce the amount of red blood cells it needs

Sections were stained with hematoxylin and eosin (H&E)

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Further mechanistic studies showed that NNMTi increases intracellular NAD levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies