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En la investigacin, el complejo con cobre (GHK-Cu) es el que muestra la mayor actividad biolgica, especialmente en lo relativo a la sntesis de colgeno y la modulacin gnica, ya que el cobre participa de forma directa en muchas de sus rutas de accin documentadas

However, it has to be remembered that, especially in the early stages of this disease, hepatocyte necrosis and intracellular antigen exposure to the immune system may result in low titer autoantibody production in WD patients, and it is a misleading point in differentiating AIH from WD [222]

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Therefore, only in rare occasions a substance is included in S0 after a case-by-case evaluation