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homologous desensitization refers to the loss of response solely to agonists that act at a particular GPCR subtype, whereas heterologous desensitization refers to a more generalized effect involving the simultaneous loss of agonist responsiveness at multiple GPCR subtypes even in the absence of agonist occupation of the other receptors

46 While ID typically causes microcytosis and vitamin B12 and folate deficiencies cause macrocytosis, the co-occurrence of these deficiencies may obscure clinical features and complicate diagnosis, leading to underestimation of the prevalence of iron, vitamin B12 and folate deficiencies

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