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During tumorigenesis, abnormal hypermethylation of the cytosine in CpG islands and hypomethylation of the whole genome result in genome instability and alterations in gene expression profile, including silencing of tumor suppressor genes, endogenous retro-elements, and tumor antigens, and activation of oncogenes (Liang and Weisenberger, 2017

Its noteworthy that in 30% of septic patients, the pathological infection cannot be detected

However, the reduction in pre-B cells during zinc deficiency mirrors the effect observed in T cells and is associated with altered glucocorticoid metabolism and increased apoptosis, highlighting shared mechanisms of immune impairment under zinc deficiency [376]

Ferroptosis was originally described as iron-dependent non-apoptotic cell death induced by compounds that selectively kill RAS -mutant cancer cells [124]