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Currently, it is estimated that there are over 55 million dementia patients worldwide, and this number may reach 150 million by 2050, imposing a significant societal burden ( Bifidobacterium , along with increased expression of inflammasomes and interleukin-1 (IL-1) in the brain, indicating that gut microbiota can trigger AD pathology through neuroinflammation ( Faecalibacterium prausnitzii isolated from healthy participants was found to alleviate cognitive deficits in a mouse model of cerebral amyloidosis ( 4.4 Parkinsons disease Parkinsons disease (PD) is a multifactorial clinical syndrome and the second most common neurodegenerative disorder globally, contributing significantly to neurological dysfunction ( The precise mechanisms connecting the neurobiological signals of the gut microbiota to the CNS remain unclear, with various hypotheses proposed

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Its primary function involves degrading reduced GSH, thereby disrupting GSH redox balance and shifting the cell towards a more oxidized state