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L.s 2008 study, Neurobiology of nicotine addiction: implications for smoking cessation treatment., Nicotine addiction operates through the alpha4beta2 brain receptor, triggering dopamine release for pleasure and mood effects

Rather than limiting growth, structured regulations promote formalization, strengthen governance across the value chain, and build consumer confidence

Footnotes: *Four additional states settled separately with the tobacco industry prior to the 1998 agreement

A data set for the IQOS tobacco heating system, a heated tobacco product manufactured by Philip Morris International, indicated that out of 24 biomarkers of potential harm, there was no statistical differences between people using the IQOS and tobacco cigarettes in 23 of 24 biomarkers (6)