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1) Patients with hypersensitivity reaction to thioctic acid (-lipoic acid) and components of this drug 2) Children and adolescents (less clinical experience) Dosage In the vein of a patient with severe symptoms, thioctic acid 600 mg per day is injected for 2 to 4 weeks, after which the drug 600 mg per day is administered orally to the patient

This process accelerates above 8C and becomes irreversible within hours at room temperature

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35 The exact significance of both the former and the latter in therapeutic terms in the management of hyperpigmentation is unknown except what can be gathered from observational studies