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Reported effects may include: Mild bloating or stomach discomfort Nausea Headache Skin rash Unpleasant taste (with sublingual use) Stop the medication and contact your provider promptly if you develop: Persistent abdominal pain or vomiting Wheezing or shortness of breath Severe rash or swelling Any unusual or worsening symptoms Trouble breathing Swelling of face, lips, or tongue Severe allergic reaction Chest pain, severe dizziness, or fainting Take exactly as prescribed

identified PERK as a specific receptor for TMAO, demonstrating that TMAO directly activates the PERK branch of the UPR at physiological concentrations, thereby inducing the transcription factor FoxO1, which is implicated in metabolic and inflammatory diseases (81)

doi: 10.1016/j.bcp.2011.12.030 160

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