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186 In fact, increased levels of cysteinyl-s-conjugates in biological fluids have been associated with several cancers, including melanoma, non-Hodgkin lymphoma, breast, ovarian and thyroid carcinomas, and with poor prognosis, recurrence and survival (see below)

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Again, this impairment is effectively bypassed by supplementation with gamma-glutamylcysteine, which can be transported into cells where it will be rapidly converted to GSH by GSH synthase