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Current protocols extrapolate from individual compound profiles and mechanistic pharmacology

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Any compound that potentiates this pathway carries a theoretical risk of promoting neoplastic processes (PMID: 34179015) No Chronic Toxicity Data: Long-term effects of sustained HGF/c-Met potentiation are unstudied even in animal models Uncharacterized Dose-Response: The relationship between Dihexa dose and adverse effects in any living system is poorly defined beyond acute preclinical studies No Regulatory Review: Dihexa has never undergone the systematic safety evaluation required for regulatory submission Safety Comparison Summary: Cerebrolysin has a known, well-characterized safety profile from decades of clinical use

3 The role of EVs in the development of different reproductive diseases 3.1 The role of EVs in the development of polycystic ovary syndrome Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disorder among women of reproductive age, characterized by ovulatory dysfunction, clinical and/or biochemical hyperandrogenism, and polycystic ovarian morphology