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These include leaf thickness, moisture content, vein structure, and overall appearance

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Deep fungal infections involving the palate or maxilla are an important differential diagnosis for the clinical entity midline destructive disease. Other conditions that fall into this category include NKT-cell lymphoma, other infections such as tertiary syphilis, granulomatosis with polyangiitis (Wegener disease), cocaine use, and epithelial malignancy of surface or salivary gland origin.34 A biopsy readily distinguishes among these entities

111,112 While smokers had much higher prevalence than non-smokers, the same pattern of greater use among youth and younger adults, declining with age, was observed in both groups (Figure 11.16, Figure 11.17)