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Liu Z, Tian Z, Zhao D, Liang Y, Dai S, Liu M, et al

Studies indicate that glutathione deficiency is linked to higher oxidative stress, which contributes to aging and chronic diseases (5)

However, increased cGMP concentration has also been observed to coincide with (NO-mediated) increases in mitochondrial biogenesis ( Alternatively, NO also stimulates mitochondrial biogenesis via the activation of 5-AMP-activated protein kinase (AMPK) ( Role of NO in mitochondrial function Nitric oxide regulates mitochondrial function both indirectly by modulating systemic responses and directly by interacting with the electron transport chain complexes