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Common Side Effects Gastrointestinal (additive): Nausea, vomiting, diarrhea, constipation and reduced appetite are the most common events and are amplified by stacking two agents that act on gut motility the dominant adverse-event category in REDEFINE [1] [2]

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Andersson BS, de Lima MJ, Saliba RM, Shpall EJ, Popat U, Jones R, Nieto Y, Hosing CM, Kebriaei P, Alousi AM, Worth LL, Madden T, Gulbis A, Chen JJ, Rondon G, McAdams P, McMullin B, Andreeff M , Champlin R

P8 had a spontaneous transverse colon perforation at the age of 51 years followed by a second perforation of the small bowel 3 days postoperatively