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These facts do not definitively disprove that Einstein had syphilis, although it appears very unlikely, but they do beg the question: Is there a more probable explanation for why Einstein developed his deadly aneurysm

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Specifically, we found younger adults who regularly used Juul might be at a relative disadvantage compared to those who used Alto based on an age by Juul versus Alto use interaction

As presented in Table 2, this pathway was not mediated by CPD, given that the association between exposure and outcome remained significant after adjusting for the potential mediator (CPD)