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Possible mechanisms The stable nicotine dependence levels over a year in e-cigarette and combined cigarette users compared to those using conventional cigarettes may be attributed to the oxidizing free-based nicotine produced by e-cigarette devices [24]

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Further research is needed to address the gaps in evidence quality and study heterogeneity, better understand the full impact of SHS on health, as well as effectively inform and enhance global tobacco control policies and public health interventions

This is largely due to the amount of wood needed for curing tobacco, with WHO estimating that one tree is needed for every 300 cigarettes produced