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Moreover, the recruitment of LC3-II to autophagosomes is mediated by the ATG5-ATG12-ATG16L complex, which also contributes to the coupling with LC3 ( Finally, after initiation, nucleation, and expansion are completed, the expanded membrane closes around the cargo to form a complete autophagosome, with the following fusion of the autophagosome with the lysosome, resulting in the formation of an autophagolysosome with degradative ability

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