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Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)

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The only slight drawbacks are its shorter filter life, overly minimalist controls which necessitate multiple combination hold-and-taps to adjust various features and a display that shuts off only on the lowest fan setting

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