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Tesamorelin, a growth hormone-releasing hormone (GHRH) analog, is specifically approved for reducing excess abdominal fat in HIV patients with lipodystrophy

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There is also discussion in the same Medical News Today article that standard trials escalate doses monthly mainly to optimize effect under defined trial conditions, but that in real-world practice, individuals differ widely in sensitivity, metabolism, side effect profile, etc

The chromophores mainly including trans-UCA(urocanic acid) in the stratum corneum and nucleotide bases in epidermal keratinocytes or immune cells (such as Langerhans cells) can absorb energy and induce the corresponding cellular damage pathway when exposed to UV light [109]