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The question remains: To what extent can any one test or biomarker adequately assay all of the individual pathways involved in such pathways and how can that information be best used to guide individual risk or even treatment

42,43 A prospective case-control study of Japanese individuals aged 40 to 85 years found that stroke risk was significantly greater among individuals with homocysteine levels of 11 mol/L or higher compared with those whose levels were less than 7 mol/L