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Reduction in corticosteroid dose may be associated with systemic withdrawal symptoms and/or unmask conditions previously suppressed by systemic corticosteroid therapy

This offers a direct reference for prostate cancer (PCa): in patients resistant to AR pathway inhibitors (e.g., abiraterone, enzalutamide), the LPA axis may serve as an analogous escape pathway. By activating non-classical AR signaling, LPA (unspecified species) drives castration-resistant PCa (CRPC)

Cibinetide also effectively reduces inflammation at nerve endings, which is particularly beneficial for pain reduction in conditions such as sciatica and other neuropathic pain states