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Copper is also bound by regulatory proteins including metallothioneins, copper chaperones (ATOX1, COX17, CCS), and the major plasma copper-binding protein ceruloplasmin

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Regarding the efficacy of oral lipoic acid supplementation, an initial short-term study in 24 patients with type 2 diabetes mellitus found that the symptoms of peripheral neuropathy improved in those who took 600 mg of lipoic acid three times a day for three weeks compared to those who took a placebo (75)