While iron chelators have demonstrated efficacy in treating transfusion-associated iron overload in thalassemia patients, their cardiovascular applications remain predominantly experimental ( Cyanidin-3-O-glucoside (C3G), an anthocyanin analog widely present in purple and red fruits and vegetables, effectively inhibits RSL3-promoted ferroptosis
For many, there are effective and less invasive options
Shastri A, Chakraborty S, Morganti C, Zaldana K, Rivera-Pea B, Zhang H, Verma D, Gitego N, Ma F, Aluri S, Pradhan K, Gordon-Mitchell S, Mantzaris I, Goldfinger M, FELDMAN EJ, Gritsman K, Shi Y, Hubner S, Yihua Q, Brown B, Khasawneh A, Skwarska A, Verma A, Konopleva M, Tabe Y, Gavathiotis E, Colla S, Gollob J, Dey J, Kornblau S , Koralov S, Ito K
In the glutaminolysis-fueled cytoplasmic NADPH-generating pathway (Figure 2E), there are 4 major mechanisms available to restore the mitochondrial matrix NADPH oxidized by IDH2