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Why bedtime dosing is preferred Endogenous GH secretion in healthy adults is tightly tied to sleep architecture, with the largest spontaneous pulse occurring within the first 60 to 90 minutes of slow wave sleep

DSIP has been investigated across multiple contexts, including sleep disorders, pain modulation, and mood regulation, though the body of clinical evidence remains limited and primarily exploratory

These hormones also influence telomerase activity and cellular senescence pathways, potentially affecting the rate of cellular aging and the accumulation of senescent cells that contribute to age-related dysfunction

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