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Search strategies and data sources All available published peer-reviewed research articles were retrieved from online electronic databases such as Google Scholar, PubMed, and Science Direct until January 2023 using keywords: (NAC OR NAC OR acetylcysteine) AND (severe acute respiratory syndrome coronavirus 2 OR SARS-CoV-2 OR COVID-19 OR severity OR mortality)

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Furthermore, owing to the limited number of therapeutic drugs, along with the emergence of drug-resistant strains, the clinical treatment of C