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Once released in the cytosol active p53 induces cellintrinsic apoptosis by activating a caspasedependent pathway likely involved in previously reported transcriptionindependent p53mediated apoptosis at the mitochondria Effectively, FOXO4-DRI is able to selectively penetrate the senescent cells without targeting healthy cells due to the use of D-amino acids instead of L-amino acids

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Cysteinyl glycine is also taken up by cells

Its biological activity is primarily driven by the reactive thiol (-SH) group on the cysteine residue, which enables participation in electron transfer and conjugation reactions