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In fact, folic acid in particular can be toxic for anyone with an MTHFR mutation

10.1016/j.plantsci.2012.01.005 Summary Keywords oxidative stress, hydrogen peroxide, dehydroascorbate, glutathione S -transferase, glutaredoxin Citation Rahantaniaina M-S, Tuzet A, Mhamdi A and Noctor G (2013) Missing links in understanding redox signaling via thiol/disulfide modulation: how is glutathione oxidized in plants

Standard glutathione is notoriously fragile

Scientists continue exploring its biological activity across numerous laboratory models involving cellular communication, tissue biology, and gastrointestinal physiology