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Lally JSV, Ghoshal S, DePeralta DK, et al

Discontinue use two weeks before surgery

Bone Healing: Preclinical research has investigated: Acceleration of fracture healing in rodent models Improved callus formation and bone density Enhanced integration of bone grafts Potential effects on osteoblast and osteoclast activity For dogs recovering from fracture repair surgeries or orthopedic procedures, these mechanisms could theoretically support healing, though clinical evidence specific to canines is limited

We note that a device must be designated under FDA's Breakthrough Devices Program to be eligible under the alternative pathway