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Placebo-controlled cross-over study of the monoaminergic stabiliser (-)-OSU6162 in mental fatigue following stroke or traumatic brain injury

At the same time, desmosterol, the immediate precursor of cholesterol in the Bloch biosynthetic pathway, together with oxysterols, binds to and activates LXRs, leading to up-regulation of genes involved in cholesterol efflux, such as ATP-binding cassette sub-family A member 1 (ABCA1), ATP-binding cassette sub-family G member 1 (ABCG1), ATP-binding cassette sub-family G member 5 (ABCG5) and ATP-binding cassette sub-family G member 8 (ABCG8), and others such as myosin regulatory light chain interacting protein (MYLIP)

10.1159/000495828 90 LiT.TimminsH