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Tirzepatide as an alternative If semaglutide is not working for you or the regulatory landscape concerns you, tirzepatide is a dual GIP/GLP-1 receptor agonist that has shown even greater weight loss in clinical trials

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While some patients have complete or near-complete symptom resolution after surgery, others have poor outcomes including persistent pain (even if the bladder is removed), complications or new symptoms with lifelong significant bother

While these responses are adaptive in the short term, prolonged exposure to high cortisol levels and chronic stress can lead to maladaptive outcomes such as immunosuppression, impaired growth, altered behaviour, and oxidative damage, leading to increased disease susceptibility and reduced performance [19, 83]