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Ferroptosis is governed by differential regulation of transcription in liver cancer

However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

doi: 10.1128/mBio.02781-18 92 HeumelSde Rezende RodovalhoVUrienCSpecqueFBrito RodriguesPRobilCet al

Three pharmacokinetic (PK) studies (total of 30 patients) have suggested that those with Gilberts syndrome have lower paracetamol glucuronidation [28, 33, 34]