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To investigate the potential relationship of the TSP with NAFLD, experiments involving gene knockout and/or gain of function along with histological evaluation could provide more evidence

Targeting the Nrf2/Heme oxygenase-1 pathway can significantly increase oxidative stress in RCC and promote apoptosis and death of cancer cells (104), while Heme oxygenase-1 has a dual role in ferroptosis induction (105)