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The GST enzymes contribute to the activation and inactivation of oxidative metabolites of carcinogenic agents correlated with cancer ( TP53 gene harbors high frequency of functional SNPs, which may alter P53 protein function ( TP53 tumor suppressor gene implicated in different cancer types, including lung cancer ( P53 SNPs and tobacco habit ( Impact of Tobacco Smoke on Genomic DNA Methylation DNA methylation plays a significant role in silencing gene expression, and changes in genomic DNA methylation patterns from the natural state will lead to the development of cancers (1)

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