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In this study, we conducted single-cell transcriptomic analysis of cells isolated from GCGR-KO mice

After 24 h, the mice were euthanized and evaluated for peptide adsorption and penetration analysis by histological examination

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Pentameric nCRP and CRP peptides 7782, 174185, and 201206 can control the inflammatory response resolving inflammation by reducing inflammatory cell endothelial adhesion and tissue migration, and the described CRP-mediated enhanced monocyte chemotaxis could be explained by local generation of mCRP (190, 191)