Such buffering could for example be mediated by activation of the Nrf2-Keap1-ARE pathway, which has been shown to be increased after polyphenol supplementation which in turn induces the expression of phase II detoxifying enzymes, responsible for reducing endogenous toxic metabolites [65]

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Lipid aldehyde levels in CSE-depleted HeLa cells following treatment with either RSL3 (5 M) or CHP (40 M) for 4 h, as measured by CHH staining (middle panel)