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CW: Formal Analysis, Methodology, Writingoriginal draft

To ensure a thorough review, we utilized multiple databases, including PubMed, Scopus, and Web of Science, and employed broad search terms related to HDTs and TB

assessed obese PCOS ladies and found that only 5 mg per day of folic acid, i.e., 25 folds the established daily need of 200 g, was effective in lowering blood Hcy compared to placebo, while the smaller dose of 1 mg daily, i.e., fivefolds the daily need, did not [19]

doi: 10.3389/fonc.2024.1525940 Received 10 November 2024 Accepted 20 December 2024 Published 21 January 2025 Volume 14 - 2024 Edited by Yue Huang, National Institutes of Health (NIH), United States Reviewed by Zhongfei Xu, China Medical University, China Updates Copyright 2025 Zhou and Shen