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Another randomized controlled trial observed the upregulation of vitamin D receptor ( VDR ), glutathione S-transferase A3 ( GSTA3 ) and interleukin 21 receptor ( IL-21R ), as well as the downregulation of prostaglandin-endoperoxide synthase 2 ( PTGS2 ), advanced glycosylation end-product specific receptor ( AGER ) and retinoid X receptor beta ( RXRB ) in women receiving vitamin D supplementation compared to placebo (80)

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Hence, patients with MCAS often go undiagnosed and continue to experience episodes whenever theyre exposed to a trigger that has yet to be identified