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A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

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In rare cases, chelation therapy can place stress on the kidneys, especially at higher doses or in individuals with pre-existing kidney issues

Effects of the catechol and methoxy metabolites of 17-estradiol on nitric oxide production by ovine uterine artery endothelial cells