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Trowbridge says that he usually prescribes isotretinoin between 5 to 6 months, depending on the dosage and severity of acne, however some patients may need to stay on the medication longer if their acne doesnt clear after 6 months or they may need a second round of treatment, and some with more mild acne may only require 4 months of treatment Treatment is usually stopped once a cumulative dose is reached and ideally after the skin has been clear for 30-60 days, which lowers the risk of relapse

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HPA Axis Modulation Oxytocin regulates the stress response by reducing HPA axis activity and cortisol levels