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Bulletin of Experimental Biology and Medicine, 137 (5), 510512

It will be interesting to determine whether aging increases DNA methylation of astrocyte-secreted Wnt factors, which might explain the lower rate of neurogenesis in old brain (Zhao et al., 2008) and the observation that early postnatal astrocytes are more efficient in promoting the in vitro neuronal differentiation of NPCs than astrocytes derived from the adult brain (Song et al., 2002)