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287 The aggregation of mutant huntingtin protein disrupts numerous cellular processes, including transcription and translation regulation, 288,289 amino acid homeostasis, 290 antioxidant and stress responses, 291,292 DNA repair, and autophagy

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Subunits of GPIT complexes are highlighted in green

For instance, in d-galactose-induced aging mice, flavonoids like epicatechin, epigallocatechin, and procyanidin B2 reversed oxidative stress by enhancing antioxidant enzymes (SOD, CAT, GSH-Px) and reducing lipid peroxidation (MDA) (Zeng et al., 2020a, b)