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Nitrosative stress leads to the overproduction of RNS, including nitric oxide (NO) which triggers an immune response, and its derivatives: nitrous acid (HNO 2 ), nitrogen dioxide (NO 2 ), and nitric acid (HNO 3 ) (91)
Thirdly, there are fundamental philosophical and practical flaws in the current evidence base of conventional medicine [Milgrom, 2014] which, when combined with an uncritical acceptance of reductionist biochemistry (as taught in many of the standard texts on the subject), can have a negative effect on the introduction of new ideas into the teaching and understanding of biomedicine [Web reference 11]
This consequently suppresses cadmium-induced changes in apoptosis-related proteins, inhibits cadmium-induced cell apoptosis, and prevents cadmium-induced mitochondrial transmembrane potential depolarization in PC12 cells [4]
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