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Studies that have evaluated changes to cytokines in response found increased TNF, IL-1, IL-3, IL-4, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IFN, KC, GM-CSF, eotaxin, MIP-1, MIP-1, and RANTES in C57BL/6 mice exposed to PG and PG with nicotine for 3 days (71)

At the same time, the button has better sealing properties, which can effectively prevent the cigarette box from opening by itself and causing the cigarette to slip out or lose

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