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Use of nicotine in tobacco, however, began long before that, potentially as early as 1400 BC, with evidence of tobacco cultivation by Mexicans and Native Americans

These groups were different from the three representative topographies identified in the first study

Autoantibodies against oxidized-LDL in smokers Smoking is associated with increased levels of Autoantibodies against oxidized-LDL In smokers, low density lipoprotein (LDL) is more prone to oxidation due to an excessive presence of reactive ROS, leading to elevated levels of antibodies against oxidized LDL (anti-oxLDL Ab)

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