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131 , e136329 (2021)

Almost 100% of the adult population in the world is infected with at least one HHV during their life 256

This coordinated release scheme is reminiscent of neuromodulatory D-serine co-transmission at NMDA receptors, and may even suggest co-release of D-serine and polyamines from astrocytes under these conditions (with the caveat that D-serine gliotransmission is controversial) (Figure 2